SPRomeDB is a freely and user friendly accessible database providing enormous human classical secretory proteins. In general, all eukaryotic cells use essentially the same pathway for synthesis and sorting of secretory proteins (referred as secretome), which are important for maintaining cell-cell communication and proliferation, and also play critical roles in metabolism and immune systems. Classes of secretory proteins in vertebrates include constitutive secretory proteins (e.g. serum proteins and extracellular matrix proteins) and regulated secretory proteins (such a peptide hormones, digestive enzymes, etc). Secretome also act an important target for therapeutic intervention to treat human diseases, and also contains extremely useful information to predict disease progression.

SPRomeDB currently contains 6,943 human secretory proteins (SPs) that were defined by a tunned analysis pipline for integrated human proteins from Swiss-Prot, TrEMBL, RefSeq, Ensembl and AceView databases. We analyzed a large number of proteomics data from the EBI, NCBI, NIST, etc databases, and RNA-Seq data, to verify secretome sequences and to reveal their tissue-specific expression patterns. SPRomeDB is expected to be a highly useful resource for human secretome proteomics research.More..